Computational studies of lipid droplets
WebJun 11, 2024 · To create a specific fluorescent reporter for lipid droplets in zebrafish, we fused tdTomato to the 3’ end of the plin2 cDNA. We chose plin2 because it is a well-known lipid droplet-associated protein that is ubiquitously expressed on lipid droplets across cell types (Olzmann and Carvalho, 2024).We generated stable transgenic zebrafish … WebMar 9, 2024 · Europe PMC is an archive of life sciences journal literature.
Computational studies of lipid droplets
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WebA significant percentage (20 to 63%) of patients with NAFLD-related HCC, however, have noncirrhotic and relatively soft tissues (13–20).We hypothesized that lipid droplets … WebOct 1, 2024 · Lipid droplets and protein handling LDs have also been implicated in various steps of the life cycle of specific proteins. LDs can assist with proper folding and assembly of higher order complexes and mediate temporary sequestration of proteins from other cellular compartments, with the best studied examples involving nuclear proteins.
WebApr 9, 2024 · Obesity results from the expansion of adipose tissue, a versatile tissue regulating energy homeostasis, adipokine secretion, thermogenesis, and inflammation. The primary function of adipocytes is thought to be lipid storage through lipid synthesis, which is presumably intertwined with adipogenesis. However, during prolonged fasting, … WebJan 6, 2024 · Lipid droplets (LDs) are neutral lipid storage organelles surrounded by a phospholipid (PL) monolayer. LD biogenesis from the endoplasmic reticulum is driven by …
WebLipid droplets, also referred to as lipid bodies, oil bodies or adiposomes, are lipid-rich cellular organelles that regulate the storage and hydrolysis of neutral lipids and are found largely in the adipose tissue. They also serve as a reservoir for cholesterol and acyl-glycerols for membrane formation and maintenance. Lipid droplets are found in all … WebMay 27, 2024 · Here, we applied a computational approach to analyze major pathways of fatty acid utilization in individual HCC. To this end, we used protein intensity profiles of …
WebDec 13, 2024 · Lipid droplets (LDs) are unique intracellular organelles that are mainly constituted by neutral lipids (triglycerides, sterol esters). As such they serve as the main site of energy storage in the cell and they are akin to oil emulsions in water. To prevent the direct exposure of the hydrophobic neutral lipids to the aqueous environment of the ...
WebOct 1, 2016 · Challenges and issues in computational studies of lipid-poor, discoidal and spheroidal lipoprotein particles. ... In CGMD simulations of lipid droplets containing CE and TG, but no apoA-I, performed by Koivuniemi et al. [133], a similar core lipid distribution to Fig. 13 C-3 was observed but with TG forming a distinct peak near the PL monolayer ... growlies pet foods incWebDec 23, 2010 · Lipid droplets (LDs) are dynamic cytoplasmic organelles containing neutral lipids and bounded by a phospholipid monolayer. Previous studies have suggested that … grow life church facebookWebA significant percentage (20 to 63%) of patients with NAFLD-related HCC, however, have noncirrhotic and relatively soft tissues (13–20).We hypothesized that lipid droplets deform the hepatocyte nucleus and serve as internal mechanical stressors, even in a soft environment, mimicking the effects of an externally stiff environment.Normal hepatocytes … grow licoriceWebMar 9, 2024 · Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage. Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs … filter aggregation in elastic searchWebComputational Studies of Lipid Droplets Author: Siyoung Kim, Jessica M. J. Swanson, Gregory A. Voth Source: Journal of physical chemistry 2024 v ... Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage. Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure with a core ... growlies recipes for 50WebMar 1, 2016 · Here, the authors study the release behavior of lipid nanodiscs from charged nano-droplets in the ESI process using microsecond atomistic molecular dynamics simulations. View Show abstract filter a hashmapWebMar 10, 2015 · Milk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells … filter a google sheet