WebMar 29, 2024 · ATG4B protein processes the viral polyprotein with its cysteine protease activity and helps EV71 replicate through a chemical biology strategy. miR-665-3p … WebIt rarely inhibits other cysteine proteases, aspartate proteases or serine proteases. Interestingly, S130 could also inhibit ATG4A in vitro owing to its high degree of similarity to protein structures of ATG4A and ATG4B; hence S130 might be the first potent inhibitor studied that has dual inhibition of ATG4B and ATG4A.

Autophagy proteins regulate ERK phosphorylation - Nature

WebCysteine proteases, also known as thiol proteases, are hydrolase enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a … ozone gel synthesis pdf

Inhibiting autophagy before it starts - PubMed

WebLC3 is a substrate of the cysteine protease ATG4B (Autophagin-1), where cleavage generates a C-terminal glycine required for LC3 conjugation to lipids in autophagosomes. ATG4B both cleaves pro-LC3 and also … WebSep 2, 2024 · ATG4B, a cysteine protease promoting autophagosome formation by reversibly modifying Atg8-family proteins, plays a vital role in controlling macroautophagy/autophagy initiation in response to stress. However, the molecular mechanism underlying the regulation of ATG4B activity is far from well elucidated. In the … WebAlthough many studies have reported that ATG4B protease is redox-regulated, more details into its molecular machinery are required. ... 69864). All the ATG4B cysteine mutants including double mutant ATG4B C292,361S were created by following the instruction of overlap Fast Mutagenesis kit (TransGen Biotech, FM111-01) and confirmed by gene ... jellybean yt face reveal