WebSep 9, 2010 · Proteasomes, the primary mediators of ubiquitin–protein conjugate degradation, are regulated through complex and poorly understood mechanisms. Here we show that USP14, a proteasome … WebJan 5, 2024 · The USP14 catalytic domain displays a classic structure similar to most USPs, resembling an extended right hand with three subdomains, a finger, palm, and thumb …
Frontiers USP14: Structure, Function, and Target Inhibition
Web69 rows · Sep 6, 2024 · Foreign Terrorist Organizations (FTOs) are foreign organizations that are designated by the Secretary of State in accordance with section 219 of the Immigration and Nationality Act (INA), as … WebJan 5, 2024 · Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein … illinois house of reps
USP14 - Wikipedia
WebUSP14. Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene. [5] [6] This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ... WebImmunoprecipitation of USP14 from 293T cell extracts using Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (lane 2) or USP14 (D8Q6S) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using USP14 (D8Q6S) Rabbit mAb. Western blot analysis of extracts from various cell lines using USP14 (D8Q6S) Rabbit mAb. WebSep 7, 2005 · Here, we report the crystal structures of the 45-kDa catalytic domain of USP14 in isolation and in a complex with ubiquitin aldehyde, which reveal distinct structural features. In the absence of ubiquitin binding, the catalytic cleft leading to the active site of USP14 is blocked by two surface loops. Binding by ubiquitin induces a significant ... illinois house redistricting