2024 Trimethyllysine dioxygenase

Trimethyllysine dioxygenase

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August undefined, 2024

WebDec 1, 2014 · Trimethyllysine hydroxylase (TMLH) catalyses the first step in carnitine biosynthesis – the conversion of N6,N6,N6-trimethyl- l -lysine to 3-hydroxy-N6,N6,N6-trimethyl- l -lysine. By changing carnitine availability it is possible to optimise cardiac energy metabolism, that is beneficial under certain ischemic conditions. WebMar 6, 2013 · During this multi-step process, N 6-trimethyllysine is converted into 3-hydroxy-N 6-trimethyllysine by trimethyllysine dioxygenase (EC 1.14.11.8) in the presence of α-KG. γ-butyrobetaine dioxygenase [EC 1.14.11.1] and betaine-aldehyde dehydrogenase (EC 1.2.1.8) are severely impeded by the Al challenge imposed on astrocytes and hepatocytes ...

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WebJan 14, 2011 · trimethyllysine dioxygenase. Synonyms. ε-trimethyllysine 2-oxoglutarate dioxygenase. oxygenase, trimethyllysine di-TML dioxygenase. TML hydroxylase. TML-α … WebEnables trimethyllysine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process and negative regulation of oxidoreductase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TMLHE (trimethyllysine hydroxylase, epsilon). geertz thick description example

Trimethyllysine dioxygenase - Wikipedia

Webaction of trimethyllysine dioxygenase (TMLD), 3-hydroxy-N-trimethyllysine aldolase and 4-N-trimethylaminobutyralde-hyde dehydrogenase. BB is hydroxylated by g-butyrobetaine dioxygenase (BBD) to form carnitine(6). Carnitine produced in liver and kidney is secreted into the blood and taken up into tissues by novel organic cation transporters (OCTN), WebFeb 5, 1986 · The data indicate that the reduction in the level of NAD kinase activation is the direct result of trimethylation of lysine 115 of calmodulin, provide a precedent for a … WebWhen trimethyllysine is released from cognate proteins via proteolysis, it serves as a precursor for carnitine biosynthesis. Mitochondrial 6-N-trimethyllysine dioxygenase converts 6-N-trimethyllysine to 3-hydroxy-6-N-trimethyllysine as the … dccs spth

Ascorbic acid: The chemistry underlying its antioxidant properties

Trimethyllysine dioxygenase

55217 - Gene ResultTMLHE trimethyllysine hydroxylase, epsilon

WebJan 14, 2011 · trimethyllysine dioxygenase. inquiry. Cat No. EXWM-0676. Description. Requires Fe2+ and ascorbate. Form. Liquid or lyophilized powder. Enzyme Commission Number. EC 1.14.11.8. CAS No. 74622-49-4. Storage. Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC. Synonyms. WebMITOCHONDRIAL DIOXYGENASE* (Received for publication, October 21, 1977) JAMES D. HULSE,$ STEVEN R. ELLIS,$ AND LAVELL M. HENDERSON From the Department of Biochemistry, College of Biological Sciences, University of Minnesota, St. ... Trimethyllysine has been used as an effective precursor of carnitine in whole animal experiments (7, 8) …

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WebConverts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded … WebHGD is organized as a complex hexameric protein, a dimer of two disklike trimers. Spatial stability is dependent on noncovalent bonds between the subunits, and the HGD enzyme function is easily disrupted by mutation.

WebMar 13, 2024 · name: trimethyllysine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3 … WebTrimethylsilyl (TMS) derivatives are frequently used for GC–MS analysis of plant hormones. Both TMS esters and ethers are formed, but when the compound of interest has both …

Webtrimethyllysine dioxygenase, mitochondrial, TML dioxygenase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, butyrobetaine (gamma), 2-oxoglutarate dioxygenase 2 (gamma-butyrobetaine hydroxylase), epsilon-trimethyllysine 2-oxoglutarate dioxygenase. GeneRIFs: Gene References Into Functions. WebThe trimethyllysine dioxygenase enzyme catalyzes the first step in the carnitine biosynthesis pathway, which is part of amine biosynthesis. Carnitine is a molecule that play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane where they are metabolized. The encoded protein converts trimethyllysine ...

WebJan 14, 2011 · Trimethyllysine dioxygenase (EC 1.14.11.8) Cite Download Contents 1 Names and Identifiers 2 Pathways 3 Biochemical Reactions 4 Catalytic Activity 5 …

WebProtein target information for Trimethyllysine dioxygenase, mitochondrial (human). Find diseases associated with this biological target and compounds tested against it in … geertz religion theoryWebMetabolite gene symbol score Taurine SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6; Sodium-dependent taurine and beta-alanine transporter. geertz theory of religionWebDec 1, 2014 · N 6-trimethyllysine dioxygenase (TMLD) is the first enzyme in the carnitine/acylcarnitine biosynthesis pathway. Inactivation of the TMLHE gene (TMLHE … geertz definition of religionWebApr 10, 2024 · The first step in carnitine biosynthesis is catalyzed by trimethyllysine hydroxylase (TMLH), a non-heme Fe (II) and 2-oxoglutarate (2OG)-dependent oxygenase, … dcc spring 2022 registrationWebOct 1, 2004 · The product of this reaction is 3-hydroxy- N6 -trimethyllysine and it appears to be the only step in which the enzyme is located in the mitochondria. 3-Hydroxy- N6 -trimethyllysine is converted to 4- N -trimethylammoniobutanal and glycine by 3-hydroxy- N6 -trimethyllysine aldolase. dccs summer programWebIn enzymology, a trimethyllysine dioxygenase is an enzyme that catalyzes the chemical reaction TMLH is a member of the alpha-ketoglutarate-dependent hydroxylases … dcc staffing services incWebThe trimethyllysine dioxygenase enzyme catalyzes the first step in the carnitine biosynthesis pathway, which is part of amine biosynthesis. Carnitine is a molecule that … geertz clifford